Integrating micro-CT and computational bone mechanics to evaluate bone treatment outcomes (Video) Event as iCalendar

(Seminars)

20 September 2016

4 - 5pm

Venue: Ground Floor Seminar Room (G10)

Location: 70 Symonds St

Dharshini Sreenivasan

A PhD exit seminar by Dr Dharshini Sreenivasan, Auckland Bioengineering Institute, University of Auckland

Abstract

We present a computational pipeline, validated on a 3D printed bone sample which underwent an Instron compression test, to assess bone failure strength in response to anabolic treatments. This pipeline was evaluated as part of three clinical studies, the highlight of which was a human clinical trial on the effects of low dose fluoride therapy in post-menopausal women. The reported failure from the Instron test formed the basis of the yield criteria for the computational work and was also able to isolate architecture from material properties for both trabecular and cortical bone. The overall outcome was the development and refinement of a computational pipeline which was integrates clinical work and was tested in a real clinical scenario to provide confidence in the use of computational models.