An open-source vascular modelling framework: from imaging to multiscale CFD (Video) Event as iCalendar

(Seminars)

28 March 2017

4 - 5pm

Venue: Ground floor seminar room (G10)

Location: 70 Symonds Street, Auckland Central

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An ABI seminar by Dr David Ladd, Auckland Bioengineering Institute.

Abstract

As computing advances have made computational fluid dynamics (CFD) models of the vasculature more tractable, their adoption into clinical application has not been equally forthcoming. In my doctoral work, I approach vascular modelling from two sides as steps toward closing this gap. First, from MRI velocimetry data, continuous fields are fitted to provide CFD boundary conditions and a means of directly estimating wall shear stress-derived disease localisation factors. Second, open-source and Physiome standards compliant methods are developed to create multiscale CFD models of vascular systems. This includes a residual-based variational multiscale method for modelling 3D flows in OpenCMISS and coupling CellML models for approximating the impedance of vascular beds and the non-Newtonian behaviour of blood. By these means, I seek to use computational methods to provide clinically relevant information and to create a framework for vascular fluid mechanical modelling that may be used, shared, and extended.