Quantifying Endothelial Mechanotransmission Event as iCalendar

(Seminars)

27 June 2017

4 - 5pm

Venue: Ground floor seminar room (G10)

Location: 70 Symonds St, Auckland Central

A Bioengineering exit seminar by Yi Chung Lim, Auckland Bioengineering Institute.

Abstract

Blood flow applies shear stresses on the vessel wall. At this interface, between the blood and wall, is a monolayer of cells known as the endothelium. How endothelial cells respond to shear stress is a key factor in the development of atherosclerosis. It may be possible to diagnose and treat atherosclerosis by targeting the endothelium, if more was understood about how the forces from blood flow are transmitted into endothelial cells.

In my PhD I have quantified mechanotransmission using a computational modelling approach that integrates haemodynamic boundary conditions, material properties of the cell, and cell morphology informed by experimental measurement. Special emphasis was placed on the effect on mechanotransmission of both 1) endothelial cell morphology and its variation at a sub-cellular, cellular and population level; and, 2) the primary cilium, a sub-cellular organelle that is involved in the earlier stages of atherosclerosis.