Auckland Bioengineering Institute
A comprehensive framework for modelling the human body.
The objective of the Physiome Project of the International Union of Physiological Sciences is to provided a comprehensive framework for modelling the human body using computational methods that can incorporate the biochemistry, biophysics and anatomy of cells, tissues and organs.
Software and web-accessible databases
To support that goal, the project is developing XML markup languages (CellML, FieldML) and software tools for creating, executing and visualising the output of computer models at the cell, tissue, organ and organ systems levels. It is also establishing web-accessible databases to provide the physiological information necessary to support these models.
Spanning the information gap
Major developments in science and medicine are the recent explosions of information in genomics and proteomics, which are providing a plethora of information relating to the regulation of cell function. On the other hand, recent developments in imaging (using MRI, CT, PET, ultrasound and electrical mapping for instance) are providing detailed information on function at organ and organ systems. The challenge of the Physiome project is to set up a model-based computational framework which spans this information gap. We see this as an important step toward the development of a patient-specific paradigm for diagnosis and treatment in the medicine of the future.
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