Auckland Bioengineering Institute


Refereed journal articles - 2013

A list of refereed journal articles authored or co-authored by staff and students at the Auckland Bioengineering Institute and published in 2013.

  • Angeli, T. R., Du, P., Paskaranandavadivel, N., Cheng, L. K., O'Grady, G., Lentle, R. G., Bissett, I. P. (2013). The bioelectrical basis and validity of gastrointestinal extracellular slow wave recordings. Journal of Physiology, 591 (18), 4567-4579. doi:10.1113/jphysiol.2013.254292
  • Angeli, T. R., O'Grady, G., Du, P., Paskaranandavadivel, N., Pullan, A. J., Bissett, I. P., & Cheng, L. K. (2013). Circumferential and functional re-entry of in vivo slow-wave activity in the porcine small intestine. Journal of Neurogastroenterology and Motility, 25 (5), e304-e314. doi:10.1111/nmo.12085
  • Angeli, T. R., O'Grady, G., Paskaranandavadivel, N., Erickson, J. C., Du, P., Pullan, A. J., Cheng, L. K. (2013). Experimental and Automated Analysis Techniques for High-resolution Electrical Mapping of Small Intestine Slow Wave Activity. Journal of Neurogastroenterology and Motility, 19 (2), 179-191. doi:10.5056/jnm.2013.19.2.179
  • Arkwright, J. W., Dickson, A., Maunder, S. A., Blenman, N. G., Lim, J., O'Grady, G., Dinning, P. G. (2013). The effect of luminal content and rate of occlusion on the interpretation of colonic manometry. Journal of Neurogastroenterology and Motility, 25 (1), e52-e59. doi:10.1111/nmo.12051
  • Aslanidi, O. V., Colman, M. A., Varela, M., Zhao, J., Smaill, B. H., Hancox, J. C., Zhang, H. (2013). Heterogeneous and anisotropic integrative model of pulmonary veins: computational study of arrhythmogenic substrate for atrial fibrillation. INTERFACE FOCUS, 3 (2). doi:10.1098/rsfs.2012.0069
  • Barrett, M. J. P., & Suresh, V. (2013). Extra permeability is required to model dynamic oxygen measurements: Evidence for functional recruitment? Journal of Cerebral Blood Flow and Metabolism, 33 (9), 1402-1411. doi:10.1038/jcbfm.2013.74
  • Ben-Tal, A., & Tawhai, M. H. (2013). Integrative approaches for modeling regulation and function of the respiratory system. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 5 (6), 687-699. doi:10.1002/wsbm.1244
  • Britten, R. D., Christie, G. R., Little, C., Miller, A. K., Bradley, C. P., Wu, A., Nielsen, P. M. F. (2013). FieldML, a proposed open standard for the Physiome project for mathematical model representation. Medical & Biological Engineering & Computing, 51 (11), 1191-1207. doi:10.1007/s11517-013-1097-7
  • Cheng, L. K., Du, P., & O'Grady, G. (2013). Mapping and modeling gastrointestinal bioelectricity: from engineering bench to bedside. Physiology (Bethesda), 28 (5), 310-317. doi:10.1152/physiol.00022.2013
  • Choi, J. H., Fahrig, R., Keil, A., Besier, T. F., Pal, S., McWalter, E. J., Maier, A. (2013). Fiducial marker-based correction for involuntary motion in weight-bearing C-arm CT scanning of knees. Part I. Numerical model-based optimization. Medical Physics, 40 (9), 091905. doi:10.1118/1.4817476
  • Choi, S., Yin, Y., Lin, C-L., Hoffman, E. A., Wenzel, S. E., Tawhai, M. H., & Castro, M. (2013). Registration-based assessment of regional lung function via volumetric CT images of normal subjects vs. severe asthmatics. Journal of Applied Physiology, 115 (5), 730-742. doi:10.1152/japplphysiol.00113.2013
  • Coveney, P. V., Diaz-Zuccarini, V., Graf, N., Hunter, P., Kohl, P., Tegner, J., & Viceconti, M. (2013). Integrative approaches to computational biomedicine. INTERFACE FOCUS, 3 (2). doi:10.1098/rsfs.2013.0003
  • Erickson, J. C., Velasco-Castedo, R., Obioha, C., Cheng, L. K., Angeli, T. R., & O'Grady, G. (2013). Automated algorithm for GI spike burst detection and demonstration of efficacy in ischemic small intestine. Annals of Biomedical Engineering, 41 (10), 2215-2228. doi:10.1007/s10439-013-0812-8
  • Fernandez, J. W., Hunter, P. J., Das, R., Cleary, P. W., Thomas, C. D. L., & Clement, J. G. (2013). Using smooth particle hydrodynamics to investigate femoral cortical bone remodelling at the Haversian level. International Journal for Numerical Methods in Biomedical Engineering, 29 (1), 129-143. doi:10.1002/cnm.2503
  • Flynn, C., Fels, S., Taberner, A. J., & Nielsen, P. M. F. (2013). Simulating the three-dimensional deformation of in vivo facial skin. Journal of the Mechanical Behavior of Biomedical Materials, 28, 484-494. doi:10.1016/j.jmbbm.2013.03.004
  • Frangi, A. F., Hose, D. R., Hunter, P. J., Ayache, N., & Brooks, D. (2013). Guest editorial special issue on medical imaging and image computing in computational physiology. IEEE Transactions on Medical Imaging, 32 (1), 1-7. doi:10.1109/TMI.2012.2234320
  • Gao, J., Du, P., O'Grady, G., Archer, R., Farrugia, G., Gibbons, S. J., & Cheng, L. K. (2013). Numerical metrics for automated quantification of interstitial cell of Cajal network structural properties. Journal of the Royal Society Interface, 10 (86), 20130421. doi:10.1098/rsif.2013.0421
  • Gerus, P., Lloyd, D. G., Sartori, M., Besier, T. F., Fregly, B. J., Banks, S. A., D'Lima, D. D. (2013). Subject-specific knee joint geometry improves predictions of medial tibiofemoral contact forces. Journal of Biomechanics, 46 (16), 2778-2786. doi:10.1016/j.jbiomech.2013.09.005
  • Gerus, P., Lloyd, D. G., Sartori, M., Besier, T. F., Fregly, B. J., Banks, S. A., D'Lima, D. D. (2013). Subject-specific knee joint geometry improves predictions of medial tibiofemoral contact forces. Journal of Biomechanics. doi:10.1016/j.jbiomech.2013.09.005
  • Gisby, T. A., O’Brien, B. M., & Anderson, I. A. (2013). Self sensing feedback for dielectric elastomer actuators. Applied Physics Letters, 102 (19). doi:10.1063/1.4805352
  • Gjuvsland, A. B., Vik, J. O., Beard, D. A., Hunter, P. J., & Omholt, S. W. (2013). Bridging the genotype-phenotype gap: What does it take? Journal of Physiology, 591 (8), 2055-2066. doi:10.1113/jphysiol.2012.248864
  • Gladding, P., Cave, A., Zareian, M., Smith, K., Hussan, J., Hunter, P., Schlegel, T. (2013). Open Access Integrated Therapeutic and Diagnostic Platforms for Personalized Cardiovascular Medicine. Journal of Personalized Medicine, 3 (3), 203-237. doi:10.3390/jpm3030203
  • Goo, S., Pham, T., Han, J. C., Nielsen, P., Taberner, A., Hickey, A., & Loiselle, D. (2013). Multiscale measurement of cardiac energetics. Clinical and Experimental Pharmacology and Physiology, 40 (9), 671-681. doi:10.1111/1440-1681.12139
  • Haber, S., Clark, A., & Tawhai, M. (2013). Blood flow in capillaries of the human lung. Journal of Biomechanical Engineering, 135 (10), 101006-101011. doi:10.1115/1.4025092
  • Han, J. C., Taberner, A. J., Nielsen, P. M., & Loiselle, D. S. (2013). Interventricular comparison of the energetics of contraction of trabeculae carneae isolated from the rat heart. J of Physiology, 591 (Pt 3), 701-717. doi:10.1113/jphysiol.2012.242719
  • Ho, H., Hunter, P., Sorrell, K., & Bartlett, A. (2013). Modeling the hepatic arterial buffer response in the liver. Medical Engineering and Physics, 35 (8), 1053-1058. doi:10.1016/j.medengphy.2012.10.008
  • Ho, H., Hunter, P., Sorrell, K., Peng, L., Yang, Z., & Holden, A. (2013). Hemodynamic analysis for transjugular intrahepatic portosystemic shunt (TIPS) in the liver based on a CT-image. IEEE Transactions on Medical Imaging, 32 (1), 92-98. doi:10.1109/TMI.2012.2219882
  • Ho, H., Mithraratne, K., & Hunter, P. (2013). Numerical simulation of blood flow in an anatomically-accurate cerebral venous tree. IEEE Transactions on Medical Imaging, 32 (1), 85-91. doi:10.1109/TMI.2012.2215963
  • Hunter, P. J. (2013). Platelet-rich blood clots. Biophysical Journal, 104 (8), 1641. doi:10.1016/j.bpj.2013.02.056
  • Hunter, P., Chapman, T., Coveney, P. V., de Bono, B., Diaz, V., Fenner, J., Viceconti, M. (2013). A vision and strategy for the virtual physiological human: 2012 update. INTERFACE FOCUS, 3 (2). doi:10.1098/rsfs.2013.0004
  • Jor, J. W. Y., Parker, M. D., Taberner, A. J., Nash, M. P., & Nielsen, P. M. F. (2013). Computational and experimental characterization of skin mechanics: identifying current challenges and future directions. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 5 (5), 539-556. doi:10.1002/wsbm.1228
  • Jowers, C. T., Taberner, A. J., Dragunow, M., & Anderson, I. A. (2013). The cell injury device: A high-throughput platform for traumatic brain injury research. Journal of Neuroscience Methods, 218 (1), 1-8. doi:10.1016/j.jneumeth.2013.04.020
  • Keenan, K. E., Pal, S., Lindsey, D. P., Besier, T. F., & Beaupre, G. S. (2013). A viscoelastic constitutive model can accurately represent entire creep indentation tests of human patella cartilage. Journal of Applied Biomechanics, 29 (3), 292-302.
  • Kim, J. H. K., Du, P., & Cheng, L. K. (2013). Reconstruction of normal and abnormal gastric electrical sources using a potential based inverse method. Physiological Measurement, 34 (9), 1193-1206. doi:10.1088/0967-3334/34/9/1193
  • Kinney, A. L., Besier, T. F., D'Lima, D. D., & Fregly, B. J. (2013). Update on grand challenge competition to predict in vivo knee loads. Journal of Biomechanical Engineering, 135 (2), 021012. doi:10.1115/1.4023255
  • Kinney, A. L., Besier, T. F., Silder, A., Delp, S. L., D'Lima, D. D., & Fregly, B. J. (2013). Changes in in vivo knee contact forces through gait modification. Journal of Orthopaedic Research, 31 (3), 434-440. doi:10.1002/jor.22240
  • Koeners, M. P., Ow, C. P., Russell, D. M., Abdelkader, A., Eppel, G. A., Ludbrook, J., Evans, R. G. (2013). Telemetry-based oxygen sensor for continuous monitoring of kidney oxygenation in conscious rats. American Journal of Physiology - Renal Physiology, 304 (12), F1471-F1480. doi:10.1152/ajprenal.00662.2012
  • Kruger, J. A., Nielsen, P. M., Budgett, S. C., & Taberner, A. J. (2013). An automated hand-held elastometer for quantifying the passive stiffness of the levator ani muscle in women. Neurourology and Urodynamics. doi: 10.1002/nau.22537
  • Kruger, J., Hayward, L., Nielsen, P., Loiselle, D., & Kirton, R. (2013). Design and development of a novel intra-vaginal pressure sensor. International Urogynecology Journal, 24 (10), 1715-1721. doi:10.1007/s00192-013-2097-8
  • Kumar, H., Vasilescu, D. M., Yin, Y., Hoffman, E. A., Tawhai, M. H., & Lin, C-L. (2013). Multi-scale imaging and registration-driven model for pulmonary acinar mechanics in the mouse. Journal of Applied Physiology, 2013 Apr;114(8):971-8. doi: 10.1152/japplphysiol.01136.2012.
  • Lau, S. Y., Chamley, L. W., Barrett, C. J., & Guild, S. -J. (2013). Necrotic trophoblast debris increases blood pressure during pregnancy. Journal of Reproductive Immunology, 97 (2), 175-182. doi:10.1016/j.jri.2012.12.005
  • Lee, A. W. C., Rajagopal, V., Babarenda Gamage, T. P., Doyle, A. J., Nielsen, P. M. F., & Nash, M. P. (2013). Breast lesion co-localisation between X-ray and MR images using finite element modelling. Medical Image Analysis, 17 (8), 1256-1264. doi:10.1016/j.media.2013.05.011
  • Lee, Y. C., Clark, A. R., Fuld, M. K., Haynes, S., Divekar, A. A., Hoffman, E. A., & Tawhai, M. H. (2013). MDCT-based quantification of porcine pulmonary arterial morphometry and self-similarity of arterial branching geometry. Journal of Applied Physiology (1985), 114 (9), 1191-1201. doi:10.1152/japplphysiol.00868.2012
  • Leung, H. Y., McCormick, D., Budgett, D. M., & Hu, A. P. (2013). Pulse density modulated control patterns for inductively powered implantable devices based on energy injection control. IET Power Electronics, 6 (6), 1051-1057. doi:10.1049/iet-pel.2012.0694
  • Lin, C-L., Tawhai, M. H., & Hoffman, E. A. (2013). Multiscale image-based modeling and simulation of gas flow and particle transport in the human lungs. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 5 (5), 643-655. doi:10.1002/wsbm.1234
  • Lippok, N., Murdoch, S. G., Wu, K. -L., & Vanholsbeeck, F. (2013). Dispersion mapping at the micrometer scale using tri-band optical frequency domain imaging. Optics Letters, 38 (16), 3028-3031. doi:10.1364/OL.38.003028
  • Lippok, N., Nielsen, P., & Vanholsbeeck, F. (2013). Single-shot speckle reduction and dispersion compensation in optical coherence tomography by compounding fractional Fourier domains. Optics Letters, 38 (11), 1787-1789.
  • Liu, X., Chen, D. Z., Tawhai, M. H., Wu, X., Hoffman, E. A., & Sonka, M. (2013). Optimal graph search based segmentation of airway tree double surfaces across bifurcations. IEEE Transactions Medical Imaging, 32 (3), 493-510. doi:10.1109/TMI.2012.2223760
  • Long, D. S., Zhu, H., & Friedman, M. H. (2013). Microscope-based near-infrared stereo-imaging system for quantifying the motion of the murine epicardial coronary arteries in vivo. Journal of Biomedical Optics, 18 (9), 096013. doi:10.1117/1.JBO.18.9.096013
  • Lu, J., Pontré, B., Pickup, S., Choong, S. Y., Li, M., Xu, H., Cooper, G. J. (2013). Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment. Cardiovascular Diabetology, 12, 28. doi:10.1186/1475-2840-12-28
  • Ma, B., Breen, B. J., & Bates, J. H. T. (2013). Influence of parenchymal heterogeneity on airway-parenchymal interdependence. Respiratory Physiology and Neurobiology, 188 (2), 94-101. doi:10.1016/j.resp.2013.06.005
  • Marc O'Brien, B., & Alexander Anderson, I. (2013). An artificial muscle computer. Applied Physics Letters, 102 (10). doi:10.1063/1.4793648
  • Medrano-Gracia, P., Cowan, B. R., Bluemke, D. A., Finn, J. P., Kadish, A. H., Lee, D. C., Young, A. A. (2013). Atlas-based analysis of cardiac shape and function: correction of regional shape bias due to imaging protocol for population studies. J of Cardiovascular Magnetic Resonance, 15, 80. doi:10.1186/1532-429X-15-80
  • Meyer, A. J., Fregly, B. J., D'Lima, D. D., Colwell Jr, C. W., Besier, T. F., & Lloyd, D. G. (2013). Are external knee load and EMG measures accurate indicators of internal knee contact forces during gait? Journal of Orthopaedic Research, 31 (6), 921-929. doi:10.1002/jor.22304
  • Mitchell, J. H., Tawhai, M. H., & Hoffman, E. A. (2013). Erratum to " Relating indices of inert gas washout to localised bronchoconstriction" [Respir. Physiol. Neurobiol. 183 (September (3)) (2012) 224-233]. Respiratory Physiology and Neurobiology, 185 (3), 665-665. doi:10.1016/j.resp.2012.11.019
  • Munro, J. T., Anderson, I. A., Walker, C. G., & Shim, V. B. (2013). Finite element analysis of retroacetabular osteolytic defects following total hip replacement. Journal of Biomechanics, 46 (14), 2529-2533. doi:10.1016/j.jbiomech.2013.07.038
  • O'Brien, B. M., Anderson, I. A., Rosset, S., & Shea, H. R. (2013). Ion implanted dielectric elastomer circuits. Applied Physics A: Materials Science and Processing, 111 (3), 943-950. doi:10.1007/s00339-012-7319-2
  • Pal, S., Besier, T. F., Beaupre, G. S., Fredericson, M., Delp, S. L., & Gold, G. E. (2013). Patellar maltracking is prevalent among patellofemoral pain subjects with patella alta: an upright, weightbearing MRI study. Journal of Orthopaedic Research, 31 (3), 448-457. doi:10.1002/jor.22256
  • Paskaranandavadivel, N., O'Grady, G., Du, P., & K Cheng, L. (2013). Comparison of filtering methods for extracellular gastric slow wave recordings. Neurogastroenterology and Motility, 25 (1), 79-83. doi:10.1111/nmo.12012
  • Petersen, S. E., Matthews, P. M., Bamberg, F., Bluemke, D. A., Francis, J. M., Friedrich, M. G., Neubauer, S. (2013). Imaging in population science: cardiovascular magnetic resonance in 100,000 participants of UK Biobank - rationale, challenges and approaches. Review in Journal of Cardiovascular Magnetic Resonance, 15. doi:10.1186/1532-429X-15-46
  • Pitto, R. P. (2013). CORR Insights™: Is limited incision better than standard total hip arthroplasty? A meta-analysis. Clinical Orthopaedics and Related Research, 471 (4), 1295-1296. doi:10.1007/s11999-013-2795-z
  • Ramsey, G. D., Hunter, P. J., & Nash, M. P. (2013). The influence of loading conditions on equine hoof capsule deflections and stored energy assessed by finite element analysis. Biosystems Engineering, 115 (3), 283-290. doi:10.1016/j.biosystemseng.2013.04.002
  • Rosset, S., Shea, H. R., O'Brien, B. M., Gisby, T., Xu, D., & Anderson, I. A. (2013). Self-sensing dielectric elastomer actuators in closed-loop operation. Smart Materials and Structures, 22 (10). doi:10.1088/0964-1726/22/10/104018
  • Shull, P. B., Cutkosky, M. R., Delp, S. L., Shultz, R., Silder, A., Dragoo, J. L., & Besier, T. F. (2013). Toe-in gait reduces the first peak knee adduction moment in patients with medial compartment knee osteoarthritis. Journal of Biomechanics, 46 (1), 122-128. doi:10.1016/j.jbiomech.2012.10.019
  • Shull, P. B., Delp, S. L., Cutkosky, M. R., Silder, A., Shultz, R., Dragoo, J. L., & Besier, T. F. (2013). Six-week gait retraining program reduces knee adduction moment, reduces pain, and improves function for individuals with medial compartment knee osteoarthritis. Journal of Orthopaedic Research, 31 (7), 1020-1025. doi:10.1002/jor.22340
  • Shultz, R., Anderson, S. C., Matheson, G. O., Marcello, B., & Besier, T. (2013). Test-retest and interrater reliability of the functional movement screen. Journal of Athletic Training, 48 (3), 331-336. doi:10.4085/1062-6050-48.2.11
  • Sieck, G. C., Mantilla, C., & Tawhai, M. (2013). Physiology's impact: discovering life. Physiology (Bethesda), 28 (4), 212-213. doi:10.1152/physiol.00027.2013
  • Silder, A., Delp, S. L., & Besier, T. (2013). Men and women adopt similar walking mechanics and muscle activation patterns during load carriage. Journal of Biomechanics, 46 (14), 2522-2528. doi:10.1016/j.jbiomech.2013.06.020
  • Smaill, B. H., Zhao, J., & Trew, M. L. (2013). Three-dimensional impulse propagation in myocardium: arrhythmogenic mechanisms at the tissue level. Circulation Research, 112 (5), 834-848. doi:10.1161/CIRCRESAHA.111.300157
  • Smith, D. W., Rubenson, J., Lloyd, D., Zheng, M., Fernandez, J., Besier, T., Gardiner, B. S. (2013). A conceptual framework for computational models of Achilles tendon homeostasis. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 5 (5), 523-538. doi:10.1002/wsbm.1229
  • Stehlin, E., Malpas, S. C., Budgett, D. M., Barrett, C. J., McCormick, D., Whalley, G., Guild, S. J. (2013). Chronic measurement of left ventricular pressure in freely moving rats. Journal of Applied Physiology (1985), 115 (11), 1672-1682. doi:10.1152/japplphysiol.00683.2013
  • Vaghefi, E., & Donaldson, P. J. (2013). An exploration into diffusion tensor imaging in the bovine ocular lens. Frontiers in Computational Physiology and Medicine , 4, 33. doi:10.3389/fphys.2013.00033
  • Vaghefi, E., Liu, N., & Donaldson, P. J. (2013). A computer model of lens structure and function predicts experimental changes to steady state properties and circulating currents. Biomedical Engineering Online, 12, 85. doi:10.1186/1475-925X-12-85
  • Wang, Y. K., Nash, M. P., Pullan, A. J., Kieser, J. A., & Röhrle, O. (2013). Model-based identification of motion sensor placement for tracking retraction and elongation of the tongue. Biomechanics and Modeling in Mechanobiology, 12 (2), 383-399. doi:10.1007/s10237-012-0407-6
  • Wu, C. C., Lin, Y. -M., Winston, J. H., Shi, X. -Z., Gao, J., & Cheng, L. K. (2013). Are Interstitial Cells of Cajal Involved in Mechanical Stress-Induced Gene Expression and Impairment of Smooth Muscle Contractility in Bowel Obstruction? PLoS ONE, 8 (9). doi:10.1371/journal.pone.0076222
  • Wu, T., Hung, A. P. -L., Hunter, P., & Mithraratne, K. (2013). Modelling facial expressions: A framework for simulating nonlinear soft tissue deformations using embedded 3D muscles. Finite Elements in Analysis and Design, 76, 63-70. doi:10.1016/j.finel.2013.08.002
  • Wu, T., Hung, A. P., Hunter, P., & Mithraratne, K. (2013). On modelling large deformations of heterogeneous biological tissues using a mixed finite element formulation. Computer Methods in Biomechanics and Biomedical Engineering. doi:10.1080/10255842.2013.818662
  • Yin, Y., Choi, J., Lin, C-L., Hoffman, E. A., & Tawhai, M. H. (2013). A multiscale MDCT image-based breathing lung model with time-varying regional ventilation. Journal of Computational Physics, 244, 168-192. doi:10.1016/j.jcp.2012.12.007
  • Young, A. A., & Prince, J. L. (2013). Cardiovascular magnetic resonance: deeper insights through bioengineering. Review in Annual Review of Biomedical Engineering, 15, 433-461. doi:10.1146/annurev-bioeng-071812-152346
  • Zhang, X., Liu, Y., Yang, M., Zhang, T., Young, A. A., & Li, X. (2013). Comparative Study of Four Time Series Methods in Forecasting Typhoid Fever Incidence in China. PLoS ONE, 8 (5). doi:10.1371/journal.pone.0063116
  • Zhao, J., LeGrice, I. J., Lever, N. A., Smaill, B. H., Yao, Y., Huang, W., Zhang, S. (2013). Novel methods for characterization of paroxysmal atrial fibrillation in Human Left Atria. Open Biomedical Engineering Journal, 7 (1), 29-40. doi:10.2174/1874120701307010029
  • Zhao, J., Legrice, I. J., Sands, G. B., Smaill, B. H., Butters, T. D., & Zhang, H. (2013). Image-based model of atrial anatomy and electrical activation: A computational platform for investigating atrial arrhythmia. IEEE Transactions on Medical Imaging, 32 (1), 18-27. doi:10.1109/TMI.2012.2227776
  • de Bono, B., Grenon, P., Baldock, R., & Hunter, P. (2013). Functional tissue units and their primary tissue motifs in multi-scale physiology. Journal of Biomedical Semantics, 4 (1), 22. doi:10.1186/2041-1480-4-22