Associate Professor Denis Scott Loiselle

MSc Alta., PhD Dal., DipPhEd Otago

Associate Professor

In: Physiology » Medical Science » Faculty of Medical and Health Sciences

Principal Investigator

Biography

Associate Professor Loiselle completed a PhD at Dalhousie University prior to a five-year stint in the laboratory of Professor Colin Gibbs at Monash University. He joined the Department of Physiology in 1982 and is a foundation member of the Auckland Bioengineering Instutute. His interest is in the thermodynamics of muscle contraction.

Research | Current

Our research comprises the design and execution of experiments to test hypotheses concerning the mechano-energetics of cardiac muscle in both the healthy state and during various forms of heart failure. We have developed technology to measure the rate of oxygen consumption of isolated, working, whole-hearts as well as the rate of heat production of isolated tissues undergoing realistic work loops, the common metric being mechanical efficiency: the ratio of macroscopic work output to metabolic energy expenditure.

Project links:

Teaching | Current

MEDSCI 142: Respiratory Physiology

MBChB 221: Respiratory Physiology

MEDSCI 309: Biophysics of Muscle Contraction

MEDSCI 725: Experimental Design

Postgraduate supervision

Principal Supervisor: Mr Toan Pham (PhD Candidate)

Co-supervisor: Ms Parisa Koutsifeli

Selected publications and creative works (Research Outputs)

Tran, K., Han, J.-C., Crampin, E. J., Taberner, A. J., & Loiselle, D. S. (2017). Experimental and modelling evidence of shortening heat in cardiac muscle. The Journal of physiology, 595 (19), 6313-6326. 10.1113/jp274680
Other University of Auckland co-authors: Kenneth Tran, June-Chiew Han, Andrew Taberner
Pham, T., Tran, K., Mellor, K. M., Hickey, A., Power, A., Ward, M.-L., ... Loiselle, D. (2017). Does the intercept of the heat-stress relation provide an accurate estimate of cardiac activation heat?. The Journal of physiology, 595 (14), 4725-4733. 10.1113/jp274174
URL: http://hdl.handle.net/2292/35048
Other University of Auckland co-authors: Kenneth Tran, Kim Mellor, Andrew Taberner, Marie-Louise Ward, Toan Pham, June-Chiew Han, Tony Hickey
Cheuk, M., Anderson, A., Han, J.-C., Lippok, N., Vanholsbeeck, F., Ruddy, B., ... Taberner, A. J. (2017). 4D imaging of cardiac trabeculae contracting in vitro using gated OCT. IEEE Transactions on Biomedical Engineering, 64 (1), 218-224. 10.1109/TBME.2016.2553154
URL: http://hdl.handle.net/2292/31774
Other University of Auckland co-authors: Andrew Taberner, June-Chiew Han, Frederique Vanholsbeeck, Bryan Ruddy, Poul Nielsen
Tran, K., Han, J.-C., Taberner, A. J., Barrett, C. J., Crampin, E. J., & Loiselle, D. S. (2016). Myocardial energetics is not compromised during compensated hypertrophy in the Dahl salt-sensitive rat model of hypertension. American journal of physiology. Heart and circulatory physiology, 311 (3), H563-H571. 10.1152/ajpheart.00396.2016
URL: http://hdl.handle.net/2292/31168
Other University of Auckland co-authors: Kenneth Tran, June-Chiew Han, Andrew Taberner, Carolyn Barrett
Chapman, B., & Loiselle, D. (2016). Thermodynamics and kinetics of the FoF1-ATPase: application of the probability isotherm. Royal Society open science, 3 (2)10.1098/rsos.150379
Loiselle, D. S., Johnston, C. M., Han, J.-C., Nielsen, P. M. F., & Taberner, A. J. (2016). Muscle heat: a window into the thermodynamics of a molecular machine. American journal of physiology. Heart and circulatory physiology, 310 (3), H311-H325. 10.1152/ajpheart.00569.2015
URL: http://hdl.handle.net/2292/28618
Other University of Auckland co-authors: Andrew Taberner, Poul Nielsen, June-Chiew Han
Loiselle, D., & Ramchandra, R. (2015). A counterview of 'An investigation of the false discovery rate and the misinterpretation of p-values' by Colquhoun (2014). Royal Society open science, 2 (8)10.1098/rsos.150217
Other University of Auckland co-authors: Rohit Ramchandra
Han, J.-C., Tran, K., Johnston, C. M., Nielsen, P. M. F., Barrett, C. J., Taberner, A. J., & Loiselle, D. S. (2014). Reduced mechanical efficiency in left-ventricular trabeculae of the spontaneously hypertensive rat. Physiological Reports, 2 (11).10.14814/phy2.12211
URL: http://hdl.handle.net/2292/26126
Other University of Auckland co-authors: Andrew Taberner, Carolyn Barrett, Kenneth Tran, Poul Nielsen, June-Chiew Han