Dr June-Chiew Han

BE(Hons) PhD

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Senior Research Fellow

Biography

June-Chiew Han received a Bachelor of Engineering (Honours) in Biomedical Engineering and a PhD in Bioengineering from the University of Auckland.

His PhD thesis involved simultaneous measurement of the heat and force production of rat cardiac trabeculae (a muscle of radial dimensions about the size of a human hair and about 3 mm long) to investigate their mechanoenergetics properties using the ABI-developed micromechanocalorimeter. An article resulting from this work appeared in the Journal of Applied Physiology.
 

Research | Current

June-Chiew's current post-doc research focuses on the effects of hypertension, hypertrophy, diabetes, and diet on cardiac energetics; specifically, how they affect myocardial mechanical efficiency. Energetic experiments are performed at the whole-heart level and at the trabecula level. Experiments are also performed at the sub-cellular level.
 

Selected publications and creative works (Research Outputs)

  • Pham, T., Nisbet, L., Taberner, A., Loiselle, D., & Han, J.-C. (2018). Pulmonary arterial hypertension reduces energy efficiency of right, but not left, rat ventricular trabeculae. The Journal of physiology, 596 (7), 1153-1166. 10.1113/jp275578
    Other University of Auckland co-authors: Toan Pham, Andrew Taberner, Denis Loiselle
  • Taberner, A. J., Zgierski-Johnston, C. M., Pham, T., Han, J. C., Uddin, R., Loiselle, D. S., ... Nielsen, P. M. F. (2018). A Flowthrough Infusion Calorimeter for Measuring Muscle Energetics: Design and Performance. IEEE Transactions on Instrumentation and Measurement10.1109/TIM.2018.2800838
    Other University of Auckland co-authors: Denis Loiselle, Andrew Taberner, Bryan Ruddy
  • Pham, T., Han, J.-C., Taberner, A., & Loiselle, D. (2017). Do right-ventricular trabeculae gain energetic advantage from having a greater velocity of shortening?. The Journal of Physiology, 595 (20), 6477-6488. 10.1113/JP274837
    Other University of Auckland co-authors: Toan Pham, Denis Loiselle, Andrew Taberner
  • Tran, K., Han, J.-C., Crampin, E. J., Taberner, A. J., & Loiselle, D. S. (2017). Experimental and modelling evidence of shortening heat in cardiac muscle. Journal of Physiology, 595 (19), 6313-6326. 10.1113/JP274680
    Other University of Auckland co-authors: Denis Loiselle, Kenneth Tran, Andrew Taberner
  • Taberner, A., Pham, T., Han, J. C., Uddin, R., & Loiselle, D. (2017). A flow-through infusion calorimeter for measuring muscle energetics during pharmacological interventions. I2MTC 2017 - 2017 IEEE International Instrumentation and Measurement Technology Conference, Proceedings. 10.1109/I2MTC.2017.7969675
    Other University of Auckland co-authors: Denis Loiselle
  • Garrett, A. S., Pham, T., Loiselle, D. S., June-Chiew Han, & Taberner, A. J. (2017). Real-time model-based control of afterload for in vitro cardiac tissue experimentation.. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 10.1109/embc.2017.8037067
    Other University of Auckland co-authors: Andrew Taberner, Denis Loiselle, Toan Pham
  • Pham, T., Tran, K., Mellor, K. M., Hickey, A., Power, A., Ward, M.-L., ... Loiselle, D. (2017). Does the intercept of the heat-stress relation provide an accurate estimate of cardiac activation heat?. The Journal of physiology, 595 (14), 4725-4733. 10.1113/jp274174
    URL: http://hdl.handle.net/2292/35048
    Other University of Auckland co-authors: Kenneth Tran, Kim Mellor, Andrew Taberner, Denis Loiselle, Marie-Louise Ward, Toan Pham, Tony Hickey, Amelia Power
  • Han, J.-C., Guild, S.-J., Pham, T., Nisbet, L., Tran, K., Taberner, A. J., & Loiselle, D. S. (2017). Left-Ventricular Energetics in Pulmonary Arterial Hypertension-Induced Right-Ventricular Hypertrophic Failure. Frontiers in physiology, 810.3389/fphys.2017.01115
    Other University of Auckland co-authors: Denis Loiselle, Sarah-Jane Guild, Kenneth Tran, Andrew Taberner