Dr Kenneth Tran
Kenneth's doctoral work focussed on developing a mathematical model of the cardiac ventricular myocyte that couples together energy demand and supply processes within the cell. This provides a tool to investigate and delineate the pathways that lead to pathologies arising from a mismatch in energy balance, such as ischaemia where a portion of the heart tissue becomes poorly perfused due to a blockage of the coronary vessels.
Subsequent to his graduation, Kenneth was appointed as a postdoctoral research fellow at the ABI.
Research | Current
Kenneth is currently working as a postdoctoral fellow on the Virtual Physiological Rat (VPR) which is an international collaboration focussed on developing models to understand and investigate the rat physiome. Kenneth is focussed on further developing his cell model and supplementing it with experimental data from rat cardiac tissue to progress the ABI's understanding of cardiac energetics.
- Lauren Dupuis (Masters, 2014)
- Megan Guidry (Masters, 2016)
Areas of expertise
Computational modelling of cardiac cellular bioenergetics.
Selected publications and creative works (Research Outputs)
- Ghosh, S., Trani, K., Crampin, E., Hanssen, E., & Rajagopa, V. (2/2/2018). Creatine-Kinase Shuttle and Rapid Mitochondrial Membrane Potential Conductivity are Needed Simultaneously to Maintain Uniform Metabolite Distributions in the Cardiac Cell Contraction Cycle. Poster presented at 62nd Annual Meeting of the Biophysical-Society, San Francisco, CA. BIOPHYSICAL JOURNAL.
- Tran, K., Han, J.-C., Crampin, E. J., Taberner, A. J., & Loiselle, D. S. (2017). Experimental and modelling evidence of shortening heat in cardiac muscle. Journal of Physiology, 595 (19), 6313-6326. 10.1113/JP274680
Other University of Auckland co-authors: Denis Loiselle, June-Chiew Han, Andrew Taberner
- Pham, T., Tran, K., Mellor, K. M., Hickey, A., Power, A., Ward, M.-L., ... Loiselle, D. (2017). Does the intercept of the heat-stress relation provide an accurate estimate of cardiac activation heat?. The Journal of physiology, 595 (14), 4725-4733. 10.1113/jp274174
Other University of Auckland co-authors: Kim Mellor, Andrew Taberner, Denis Loiselle, Marie-Louise Ward, Toan Pham, June-Chiew Han, Tony Hickey, Amelia Power
- Tran, K. (2017). Shortening Heat In Cardiac Muscle. Paper presented at Annual Meeting of the American-Society-for-Pharmacology-and-Experimental-Therapeutics (ASPET) at Experimental Biology Meeting, Chicago, IL. 22 April - 26 April 2017. FASEB JOURNAL. (pp. 1).
- Han, J.-C., Guild, S.-J., Pham, T., Nisbet, L., Tran, K., Taberner, A. J., & Loiselle, D. S. (2017). Left-Ventricular Energetics in Pulmonary Arterial Hypertension-Induced Right-Ventricular Hypertrophic Failure. Frontiers in physiology, 810.3389/fphys.2017.01115
Other University of Auckland co-authors: Denis Loiselle, June-Chiew Han, Sarah-Jane Guild, Andrew Taberner
- Pham, T., Han, J.-C., Tran, K., Power, A., Ward, M. L., Mellor, K., ... Loiselle, D. (21/9/2016). Blebbistatin reveals length-dependence of the metabolic cost of activating contraction in cardiac muscle. Poster presented at 7th International workshop on cardiac mechano-electric coupling and arrhythmias, Freiburg, Germany. Related URL.
Other University of Auckland co-authors: Marie-Louise Ward, Toan Pham, June-Chiew Han, Amelia Power, Kim Mellor, Tony Hickey, Andrew Taberner, Denis Loiselle
- Tran, K., Han, J.-C., Taberner, A. J., Barrett, C. J., Crampin, E. J., & Loiselle, D. S. (2016). Myocardial energetics is not compromised during compensated hypertrophy in the Dahl salt-sensitive rat model of hypertension. American Journal of Physiology - Heart and Circulatory Physiology, 311 (3), H563-H571. 10.1152/ajpheart.00396.2016
Other University of Auckland co-authors: June-Chiew Han, Andrew Taberner, Carolyn Barrett, Denis Loiselle
- Tran, K., Loiselle, D. S., & Crampin, E. J. (2015). Regulation of cardiac cellular bioenergetics: mechanisms and consequences. Physiological reports, 3 (7).10.14814/phy2.12464
Other University of Auckland co-authors: Edmund Crampin, Denis Loiselle