Auckland Bioengineering Institute
Systems Biology Group
Systems Biology is the study of an organism's biology and physiology as an integrated network of genes, proteins and other molecules linked by the biochemical reactions taking place within, and between, cells. Rather than studying individual genes or proteins, Systems Biologists work with experimentalists to mathematically model the function of the biochemical pathways in which these molecules interact.
The Systems Biology group at The Auckland Bioengineering Institute (ABI) is developing models and tools for the analysis of biological pathways and networks and applying these techniques to a variety of problems in human physiology and disease, including gene networks underlying skin and breast cancer, and the systems biology of heart disease.
- Project members and collaborators
- Project publications
- Read more information about this group's work on Dr Crampin's homepage
This is a list of the Doctoral and Masters projects related to this research programme. Future Postgraduates interested in these projects are encouraged to contact Dr Mike Cooling, m.cooling@auckland.ac.nz, for further information.
Understanding the intracellular events which lead to vascular wall mal-adaptation
Degree level: Doctoral
Funding: Partial funding from Marsden Grant
We aim to help treat and prevent cardiovascular disease, the developed world’s major killer. The project involves mathematical modelling, laboratory experimentation and computational analysis of key intracellular events leading to vascular wall mal-adaptation, which can lead to (for example) aneurysm formation or atherosclerosis. There is a significant international component, via existing collaborations with MIT (USA), BioSym (Singapore), Monash (Australia) and Newcastle-Upon-Tyne (UK). The mathematical models will also form foundational entries in a repository of cell-signalling models for use by researchers worldwide. Previous experience in the specific methods is not necessary. This project represents an exciting platform for a self-motivated candidate who will make the most of the multiple opportunities presented.
Degree level: Masters
Funding: This project has a grant from the Marsden Fund to support two Masters students for up to $5,200 for fees and $16,000 stipend per student
We aim to help treat and prevent cardiovascular disease, the developed world’s major killer. These projects involve the mathematical modelling of previously identified key intracellular events leading to vascular wall mal-adaptation, which can lead to (for example) aneurysm formation or atherosclerosis. The mathematical models will also form foundational entries in a repository of cell-signalling models for use by researchers worldwide. Previous experience in the specific methods is not necessary.
The Systems Biology and Cell Modelling Group gratefully acknowledges the support of its funding partners:
- The Marsden Fund, The Royal Society of New Zealand
- Health Research Council of New Zealand, International Investment Opportunities Fund
- Maurice Wilkins Centre for Molecular Biodiscovery
- The University of Auckland Research Committee
-
Supporting us
