Auckland Bioengineering Institute
Mike Cooling
Research Fellow
BSc BCom(Hons) GradDipSci PhD
Contact details
UniServices House, Room 617
70 Symonds Street
Auckland
Phone +64 9 3737599 ext 81492
Email: m.cooling@auckland.ac.nz
Profile
Mike has a background in software development and management consulting. He is a Research Scientist at the Auckland Bioengineering Institute with interests in modularity and reuse of CellML models, mathematical cardiology, computational immunology, modelling workflow, signal transduction pathways and synthetic biology.
Research interests
Mike is driven by a desire to understand how cells work. He is particularly interested in signal transduction: from hormone or mechanical stimulation on the outside of the cell to changes in gene regulation on the inside.
These systems are so complex that only a few functions at a time can be examined experimentally, hence Mike employs Systems Biology techniques - using mathematical modelling to build and analyse 'in silico' replicas of cell function.
His particular focus is on cardiovascular disease, examining the initiation of concentric hypertrophy in cardiac myocytes, and lately the development of vascular mal-adaptation in endothelial, vascular smooth muscle and fibroblast cells.
Mike draws on concepts from computer science to develop practices, annotations and ontologies to support modular modelling of complex systems for Systems Biology and applied sub-disciplines.
Project links
Further information
Read more information about Dr Cooling's research interests and publications at his personal website.
